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1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Article
in English
| MEDLINE | ID: mdl-34822784
2.
The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2.
Exp Physiol
; 109(1): 81-99, 2024 01.
Article
in English
| MEDLINE | ID: mdl-37656490
3.
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Nat Chem Biol
; 16(3): 240-249, 2020 03.
Article
in English
| MEDLINE | ID: mdl-32080630
4.
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.
Mol Pharmacol
; 93(6): 645-656, 2018 06.
Article
in English
| MEDLINE | ID: mdl-29695609
5.
In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography.
J Pharmacol Exp Ther
; 365(3): 602-613, 2018 06.
Article
in English
| MEDLINE | ID: mdl-29643252
6.
An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.
J Biol Chem
; 291(17): 8862-75, 2016 Apr 22.
Article
in English
| MEDLINE | ID: mdl-26826123
7.
Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors.
Eur J Neurosci
; 45(12): 1570-1585, 2017 06.
Article
in English
| MEDLINE | ID: mdl-28406538
8.
Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
Cereb Cortex
; 26(1): 414-26, 2016 Jan.
Article
in English
| MEDLINE | ID: mdl-26472558
9.
TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde-Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology.
Clin Pharmacol Ther
; 114(5): 1093-1103, 2023 Nov.
Article
in English
| MEDLINE | ID: mdl-37562824
10.
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors.
Br J Pharmacol
; 176(1): 110-126, 2019 01.
Article
in English
| MEDLINE | ID: mdl-30276808
11.
Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors.
Mol Pharmacol
; 73(6): 1838-43, 2008 Jun.
Article
in English
| MEDLINE | ID: mdl-18367540
12.
Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases.
Neuropharmacology
; 136(Pt C): 449-458, 2018 07 01.
Article
in English
| MEDLINE | ID: mdl-29374561
13.
Synthesis and Pharmacological Characterization of C4ß-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist.
J Med Chem
; 61(6): 2303-2328, 2018 03 22.
Article
in English
| MEDLINE | ID: mdl-29350927
14.
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist.
Neuropharmacology
; 115: 100-114, 2017 03 15.
Article
in English
| MEDLINE | ID: mdl-26748052
15.
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.
J Clin Invest
; 127(2): 487-499, 2017 Feb 01.
Article
in English
| MEDLINE | ID: mdl-27991860
16.
5-I A-85380 and TC-2559 differentially activate heterologously expressed alpha4beta2 nicotinic receptors.
Eur J Pharmacol
; 539(1-2): 10-7, 2006 Jun 06.
Article
in English
| MEDLINE | ID: mdl-16674940
17.
Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells.
Biochem J
; 389(Pt 3): 821-9, 2005 Aug 01.
Article
in English
| MEDLINE | ID: mdl-15918794
18.
TRPV3 in Drug Development.
Pharmaceuticals (Basel)
; 9(3)2016 Sep 09.
Article
in English
| MEDLINE | ID: mdl-27618069
19.
Activation of transient receptor potential ankyrin 1 induces CGRP release from spinal cord synaptosomes.
Pharmacol Res Perspect
; 3(6): e00191, 2015 Dec.
Article
in English
| MEDLINE | ID: mdl-27022465
20.
123I-iododexetimide preferentially binds to the muscarinic receptor subtype M1 in vivo.
J Nucl Med
; 56(2): 317-22, 2015 Feb.
Article
in English
| MEDLINE | ID: mdl-25593117